Graham, known for his long essays on startups, economics, and the tech industry, was one of the first to comment on the importance of taste in a 2002 essay in which he claimed “taste” is not objective and that “we need good taste to make good things.”
Solexa’s first product, the Genome Analyzer, launched in 2006 with a retail price of $400,000, and the company was acquired by the American genomics firm Illumina the following year. In 2008, the company published a paper demonstrating their technology’s ability to efficiently sequence whole genomes via short reads. Illumina’s method is commonly known as “sequencing by synthesis.” While the label could technically be applied to other methods, including Sanger’s, which also indirectly assesses sequence by detecting the incorporation of nucleotides complementary to the template strand, it’s most commonly used to refer to Illumina’s chemistry.
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